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February 1973

Howell-Jolly BodiesIntracellular or Extracellular?

Author Affiliations

Columbus, Ohio

From the Division of Hematology, Department of Medicine, Ohio State University College of Medicine, Columbus.

Arch Intern Med. 1973;131(2):236-237. doi:10.1001/archinte.1973.00320080072009

Howell-Jolly (H-J) bodies have classically been considered intracellular remnants of the normoblast nucleus that once occupied the red blood cell in which the inclusion is seen. Recent work, supported by light microscopic findings, has suggested these inclusions may be extracellular. Extensive scanning and electron microscopic study of H-J red blood cells has confirmed their intracellular location.