Clinical trials of disseminated Hodgkin's disease were carried out during the last ten years by Acute Leukemia Group B. A gradual development of intensification of therapy has taken place from unmaintained singleagent treatment to intensive multiple-agent therapy followed by long-term maintenance, with corresponding improvement of frequency and duration of remissions.
Nissen NI, Stutzman L, Holland JF, Glidewell OJ. Chemotherapy of Hodgkin's Disease in Studies by Acute Leukemia Group B. Arch Intern Med. 1973;131(3):396-401. doi:10.1001/archinte.1973.00320090086010