Delayed hypersensitivity was studied in 103 untreated patients with Hodgkin's disease in all four stages, using six skin test antigens. Forty-three had phytohemagglutininstimulated peripheral leukocyte cultures. Four- to five-year follow-up data relate initial skin test reactivity and lymphocyte transformation to course and survival. Only 11.7% failed to react to any of the six skin tests. Anergy incidence increased with stage. Mumps and 2,4-dinitrochlorobenzene (DNCB) most frequently yielded positive re- actions. Reactivity correlated with the absence of systemic symptoms as well as with histologic type, and did not correlate with course and survival when compared by stage. Nor did phytohemagglutinin-induced lymphocyte transformation correlate with survival, frequency of relapse, or remission duration. Initial delayed hypersensitivity and lymphocyte transformation does not influence prognosis and survival in Hodgkin's disease.
Young RC, Corder MP, Berard CW, DeVita VT. Immune Alterations in Hodgkin's DiseaseEffect of Delayed Hypersensitivity and Lymphocyte Transformation on Course and Survival. Arch Intern Med. 1973;131(3):446–454. doi:10.1001/archinte.1973.00320090136016