Non-Hodgkin's lymphoma represents a spectrum of lymphoproliferative disorders from well-differentiated lymphocytic to more malignant, poorly differentiated, and histiocytic varieties. The disease is often generalized and marrow invasion is common. Radiotherapy for localized disease can be curative. Combination chemotherapy increases the response rate and duration.
Carbone PP. Management of Patients With Non-Hodgkin's Lymphoma. Arch Intern Med. 1973;131(3):455-459. doi:10.1001/archinte.1973.00320090145017