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Article
July 1973

Levodopa and Induced-Pain ResponseA Study of Patients With Parkinsonian and Pain Syndromes

Author Affiliations

New York

From the departments of neurosurgery, medicine, and psychiatry, New York University Medical School.

Arch Intern Med. 1973;132(1):70-74. doi:10.1001/archinte.1973.03650070062009
Abstract

The responses of 11 parkinsonian patients were evaluated by three standard laboratory pain-inducing techniques involving radiant heat, cold pressor, and electrical stimulation, before and during therapy with levodopa. All techniques measured three pain-response parameters—pain threshold, pain tolerance, and pain sensitivity range. The patients' psychological ability to endure pain was not significantly altered, and no consistent changes were observed with cold pressor and electrical stimulation. However, the highly significant correlations found between levodopa dosage and the increases in radiant heat pain threshold and pain tolerance (P <.01) suggest that patients became less sensitive to heat stimulation while taking levodopa.

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