July 1973

Chondrocalcinosis Articularis (Pseudogout Syndrome)

Author Affiliations


From the Case Western Reserve University School of Medicine (Dr. Moskowitz) and University Hospitals (Dr. Garcia), Cleveland.

Arch Intern Med. 1973;132(1):87-91. doi:10.1001/archinte.1973.03650070077012

Clinical, roentgenographic, and synovial fluid findings in 43 patients with chondrocalcinosis articularis (pseudogout syndrome) are analyzed and compared to those in previous series. The age of the patients at time of diagnosis ranged from 41 to 83 years; 33 patients were 60 years or older at time of diagnosis. Large joints were most commonly involved. Acute, subacute, and chronic arthritis were noted; chronic low-grade arthralgias were common. Results of serum calcium and phosphorus determinations were normal. Crystals identifiable as calcium pyrophosphate dihydrate were noted in synovial fluid study; in one patient, dicalcium phosphate dihydrate crystals were identified as well. Degenerative joint disease and rheumatoid arthritis were frequent associated findings. Acute symptoms had varying responses to intra-articular corticosteroid, colchicine, indomethacin, or phenylbutazone administration. Aspirin relieved chronic low-grade arthralgias.