July 1973

Tolerance, Autoimmunity and Aging.

Author Affiliations

San Francisco


Edited by M. Michael Sigel, PhD, and Robert A. Good, MD, PhD. Price, $18.75. Pp 181. Charles C Thomas Publisher, 301-327 E Lawrence Ave, Springfield, IL 62703, 1972.

Arch Intern Med. 1973;132(1):139. doi:10.1001/archinte.1973.03650070125024

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This 1972 American Lecture Series publication is the offspring of a two-day symposium held in February 1970. The result is a group of loosely connected papers prepared by highly sophisticated basic science investigators. It will become apparent to the clinician who reads this publication that the traditional pillars of immunologic research, the rabbit and the guinea pig, have been all but replaced by carefully pedigreed strains of mice.

The contemporary question of tumor formation and its relation to the title is outlined by Teller. Subsequent chapters by outstanding workers, including Robert Good, entertain further details of humoral and cellular hypersensitivity and the systems responsible for immunologic competence.

The role of viral-induced infection (again, in laboratory animals) is covered in newborn and aging mice. A number of arguments are presented to support the theory that viruses effect a change in antigens which then become responsible for the aging process.

The final

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