Fifteen patients with Raynaud syndrome affecting both hands equally were given reserpine intraarterially in one arm and a control solution in the other. There was short-term improvement in three of the 15 patients' conditions. We concluded that reserpine intraarterially is not an effective treatment for Raynaud syndrome.
McFadyen IJ, Housley E, MacPherson AIS. Intraarterial Reserpine Administration in Raynaud Syndrome. Arch Intern Med. 1973;132(4):526-528. doi:10.1001/archinte.1973.03650100044008