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October 1973

Pituitary GigantismA Case Report and Review

Author Affiliations

Birmingham, Ala

From the Department of Medicine, University of Alabama; the Veterans Administration (Drs. Haigler and Hershman) Birmingham, Ala. Dr. Haigler is now also with the Carraway Methodist Medical Center, Birmingham, Ala. Dr. Meador is now with St. Thomas Hospital, Nashville.

Arch Intern Med. 1973;132(4):588-594. doi:10.1001/archinte.1973.03650100096018

Prior to the end of the 19th century, many reports dealing with acromegaly and gigantism appeared. The two syndromes were related to each other clinically by Brissaud and Miege in 18951; Hutchinson described pathologic similarity in 1900.2 Thirty-two years later Cushing reaffirmed that pituitary adenomata were regularly found in patients manifesting either acromegaly or gigantism. He expressed the theory that the relative rarity of pituitary gigantism resulted from the recognized lack of adenoma formation in early life.3 Following Cushing's writings of 1927, scattered case reports dealing with the subject of pituitary gigantism appeared.4-7 Recent reports presented the first detailed studies of human growth hormone (HGH) levels and their response to various manipulations in two giants.8,9 However, it is still true that much of what is written in textbooks regarding pituitary gigantism is derived by inference from what is known of the more common adult syndrome

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