[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.87.114.118. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1974

Prostaglandins and the Central Nervous System

Author Affiliations

Toronto

From the Research Institute, Hospital for Sick Children, Toronto.

Arch Intern Med. 1974;133(1):119-129. doi:10.1001/archinte.1974.00320130121010
Abstract

Prostaglandins are found diffusely throughout the central nervous tissue, which is endowed with complete systems capable of synthesizing and metabolizing distinct prostaglandin types. In addition, these compounds are found in the cerebrospinal fluid. Prostaglandin actions are varied and include effects on behavior, regulation of food intake, body temperature, and cardioregulatory and motor functions. These compounds probably function as modulators or mediators of humoral and other stimuli to neurons. The mechanisms have not been precisely defined. Evidence suggests that prostaglandins are functionally related to the adenyl cyclase-cyclic adenosine monophosphate system. This report deals with literature surveyed up to April 1973.

×