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Article
February 1974

Pregnancy in a Patient With Hormone Deficiency

Author Affiliations

Salt Lake City

From the Laboratory for the Study of Hereditary and Metabolic Disorders, Division of Metabolism, Department of Internal Medicine and Clinical Research Center, University of Utah College of Medicine (Drs. Bowers and Jubiz), and the Veterans Administration Hospital (Dr. Jubiz), Salt Lake City. Dr. Bowers is now with the US Army Hospital in Hawaii.

Arch Intern Med. 1974;133(2):312-314. doi:10.1001/archinte.1974.00320140150018
Abstract

Pituitary apoplexy may lead to a deficiency of one, several, or all of the pituitary trophic hormones. Failure of growth hormone secretion is the most common and usually the earliest manifestation to appear in patients with pituitary insufficiency.1 Recently we had the opportunity to study a young woman with postpartum pituitary necrosis (Sheehan Syndrome) and deficiencies of luteinizing hormone, thyroid-stimulating hormone, and adrenocorticotrophic (ACTH) hormone, although her pituitary gland retained the ability to secrete growth hormone. In spite of the multiple trophic hormone deficiencies, the patient became pregnant.

Patient Summary  A 21-year-old white woman entered the hospital with a chief complaint of lethargy of nine months' duration. She had been well until five days before the delivery of her first child at which time the membranes ruptured. During the night before delivery, she became febrile (39.4 C) and remained so throughout the course of her labor. After labor was

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