In Jamaica, leg ulcers are a major manifestation of sickle cell disease. The chronicity of the lesions is such that education and consequent work potential are seriously affected. Although these lesions rarely cause mortality, they are a major determinant of the morbidity of the disease.
Serjeant GR. Leg Ulceration in Sickle Cell Anemia. Arch Intern Med. 1974;133(4):690-694. doi:10.1001/archinte.1974.00320160184017