Adrenal diseases are responsible for only about 1% of cases of hypertension. However, these diseases need to be considered in many more patients with unusual symptoms, signs, and laboratory data. Procedures are readily available to rule out these diseases with relative ease and great accuracy. Those patients with positive screening tests can be subjected to more intensive work-up to confirm the diagnosis. Definitive therapy, either medical or surgical, usually relieves the hypertension.
Kaplan NN. Adrenal Causes of Hypertension. Arch Intern Med. 1974;133(6):1001-1006. doi:10.1001/archinte.1974.00320180119010