With the availability of effective antihypertensive drugs, it has become possible to reduce significantly the morbidity and mortality from cardiovascular complications of hypertension. Among the more potent agents that maintain a reduced arterial blood pressure are those that inhibit sympathetic activity; this inhibition may be achieved at practically any anatomical level of adrenergic function. However, for these compounds to maintain and enhance their effectiveness, they must be used in conjunction with diuretics. The following discussion reviews each of these adrenolytic agents, describing their respective mechanisms of action, hemodynamic effects, their clinical uses, and side effects.
Frohlich ED. Inhibition of Adrenergic Function in the Treatment of Hypertension. Arch Intern Med. 1974;133(6):1033-1048. doi:10.1001/archinte.1974.00320180151013