August 1974

Hereditary Hemorrhagic Telangiectasia and Factor VIII Deficiency

Author Affiliations

Birmingham, Ala

From the Department of Medicine, University of Alabama Hospitals and Clinics, Birmingham. Dr. Skilling was a senior medical student at the time of this study. He is now on active duty with the US Marines on Okinawa.

Arch Intern Med. 1974;134(2):327-329. doi:10.1001/archinte.1974.00320200137020

Until the early 20th century, hereditary hemorrhagic telangiectasia (HHT) was confused with hemophilia. The distinction between the two was clarified by Rendu, Osier, Weber and others, and since then these two disorders have been regarded as separate clinical entities.1-3 The possibility of their chance coexistence in the same patient was suggested by Hanes in 1909.4 In 1968, Quick alluded to a patient with both HHT and mild hemophilia A (antihemophilic globulin deficiency, factor VIII deficiency) and mentioned the patient's severe gastrointestinal tract bleeding, but gave no details.5 We believe ours to be the first report of hereditary hemorrhagic telangiectasia occurring in a patient with proven factor VIII deficiency.

Patient Summary  A 78-year-old white man, a retired railroad foreman, in the past 18 years has had 56 admissions to the Birmingham and Montgomery (Ala) Veterans Administration hospitals for various hemorrhagic episodes. He related a history of prolonged bleeding

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