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September 1974

Intermediary Metabolism of the Liver.

Arch Intern Med. 1974;134(3):598-599. doi:10.1001/archinte.1974.00320210208042

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This book is a collection of individual contributions by ten authors on selected aspects of hepatic intermediary metabolism. The topics include observations on protein, carbohydrate, and lipid metabolism in the context of acute toxic liver injury, with carbon tetrachloride as a model of action on peroxidative decomposition of lipids in cell membrane and endoplasmic reticulum. Adenosine triphosphatase (ATP) depletion as a causative factor in several human hepatic disorders is discussed in relation to the concept that derangement of central energy metabolism has a profound effect on major protein, lipid, and carbohydrate bodily mechanisms. Depletion of hepatic ATP induced by ethionine, methionine, fructose, orotic acid, and tryptophan in experimental laboratory models is reviewed. The author is careful to note that ATP concentrations in human hepatic cells have not been measured often, although ATP concentrations can be determined in human red blood cells. The implication that hypophosphatemia may greatly alter cellular energy

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