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October 1974

Intracisternal and Intrathecal Injections of Gentamicin in Enterobacter Meningitis

Author Affiliations

From the Infectious Diseases and Immunology Division, Department of Medicine, Medical University of South Carolina, Charleston, SC.

Arch Intern Med. 1974;134(4):738-740. doi:10.1001/archinte.1974.00320220140019

An adult patient with meningitis due to Enterobacter cloacae associated with spinal subarachnoid block resulting from a gunshot wound and neurosurgical procedures at the level of C5-6 was treated successfully with intramuscular, intrathecal, and intracisternal doses of gentamicin. Simultaneous injections of gentamicin were given into the cisterna magna (5 mg) and lumbar intrathecal space (5 to 10 mg) for a total intrathecal dose of 70 mg in ten days. This dosage is higher than that usually described in the literature. The patient recovered from the infection.