An adult patient with meningitis due to Enterobacter cloacae associated with spinal subarachnoid block resulting from a gunshot wound and neurosurgical procedures at the level of C5-6 was treated successfully with intramuscular, intrathecal, and intracisternal doses of gentamicin. Simultaneous injections of gentamicin were given into the cisterna magna (5 mg) and lumbar intrathecal space (5 to 10 mg) for a total intrathecal dose of 70 mg in ten days. This dosage is higher than that usually described in the literature. The patient recovered from the infection.
Saad AF, Farrar WE. Intracisternal and Intrathecal Injections of Gentamicin in Enterobacter Meningitis. Arch Intern Med. 1974;134(4):738-740. doi:10.1001/archinte.1974.00320220140019