Making the diagnosis of α-chain disease in the laboratory is difficult. Immunologic and structural characteristics of the abnormal protein were shown in results of cellular studies. There are clinicopathological features associated with the protein abnormality. The peculiar geographic origin of patients affected with α-chain disease and the possible reversibility of the hyperplastic process at its early stage lead to some considerations of cause.
Seligmann M. Immunochemical, Clinical, and Pathological Features of a-Chain Disease. Arch Intern Med. 1975;135(1):78-82. doi:10.1001/archinte.1975.00330010080011