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February 1975

Rheumatoid Arthritis Associated With Hyperviscosity Syndrome and Intermediate Complex Formation

Author Affiliations

From Michael Reese Hospital, Chicago (Drs. Fletcher, Mamby, and Shapiro) and the Department of Medicine, University of Washington, Seattle (Dr. Pope). Dr. Fletcher is with the Department of Medicine, University of Miami, Coral Gables, Fla, and Dr. Pope is now in the military.

Arch Intern Med. 1975;135(2):281-285. doi:10.1001/archinte.1975.00330020085011

A patient with long-standing rheumatoid arthritis developed hyperviscosity syndrome that correlated with the presence of abundant intermediate complexes in plasma. The intermediate complexes were isolated, and evidence is presented that these complexes are composed predominantly of IgG-rheumatoid factor.