April 1975

Recommended Treatment Schedules for Gonorrhea—1974

Author Affiliations

Director Venereal Disease Control Division Bureau of State Services Atlanta

From the Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, Atlanta.

Arch Intern Med. 1975;135(4):615-618. doi:10.1001/archinte.1975.00330040127022

The Public Health Service has requested that the latest recommended treatment schedules for gonorrhea be widely distributed among physicians, since the incidence of the disease appears to be increasing sharply.Ed.

Physicians are cautioned to use no less than the recommended dosages of antibiotics.


Drug Regimen of Choice  The regimen of choice is aqueous procaine penicillin G, administered at a dose of 4.8 million units intramuscularly, divided into at least two doses and injected at different sites at one visit, together with 1 gm of probenecid, by mouth, just before the injections.

Alternative Regimens 

  1. Patients in whom oral therapy is preferred should take ampicillin, 3.5 gm, by mouth, together with 1 gm probenecid by mouth, administered at the same time. There is evidence that this regimen may be slightly less effective than the recommended treatment with aqueous procaine penicillin G.

  2. Patients who

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