April 1975

The Influences of Pancreatic Tumors on the Stomach,

Author Affiliations

Lakeland, Fla


by Robert M. Zollinger, MD, and David W. Coleman, 205 pp, $11.75, Charles C Thomas, Publisher, 1974.

Arch Intern Med. 1975;135(4):627. doi:10.1001/archinte.1975.00330040139033

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The author of this book is especially qualified to discuss non-insulin-secreting pancreatic islet tumors, since it was his classic publication in 1955 that led to renewed interest in so-called "non-functioning" islet tumors.

The first section of the book is a masterful coverage of the entity he modestly calls the ulcerogenic syndrome, although it is known around the world by his name. The text is replete with pictures of scientific contributors, as well as tables and illustrations elucidating basic pathophysiologic concepts.

The second part of the book reviews the diarrheogenic syndrome—another symptom complex associated with non-beta-islet tumors. Although the diarrheogenic hormone or substances elaborated by the tumors have not been conclusively characterized, the author presents current suspected possibilities, including secretin, gastrone, and a combination of the polypeptides, gastrone and glucagon. The omission of data incriminating gastric inhibitory polypeptide is probably due to its very recent publication. The clinical aspects of this

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