May 1975

Diphenylhydantoin Treatment

Arch Intern Med. 1975;135(5):745. doi:10.1001/archinte.1975.00330050119022

To the Editor.  —Inquiries directed to me since the publication of an article entitled "Diphenylhydantoin Treatment of Glycogen Storage Disease" by Jubiz and Rallison in the September 1974 issue of the Archives prompt me to point out that those data published in this report that are the results of analyses done in my laboratory were published without my prior approval. The hepatic glycogen contents given in Table 3 and the inclusion of the assay conditions in the Methods section, as well as the values reported in Table 4, have been interpreted by some readers as implying that I am in agreement with two of the conclusions drawn by the authors, namely, that a reduction in hepatic glycogen content was demonstrated as a result of the therapy given, and that a concomitant induction of hepatic enzymes might have been anticipated. The control value reported for patient 1 was obtained in February

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