May 1975

Diphenylhydantoin Treatment-Reply

Author Affiliations

Salt Lake City

Arch Intern Med. 1975;135(5):745. doi:10.1001/archinte.1975.00330050119023

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To the Editor.  —We are most grateful to Dr. Brown for her assistance in performing the glycogen and enzyme assays for us, and we genuinely regret that a misunderstanding has occurred. The results of hepatic glycogen content were discussed with her on several occasions. Subsequent to one of those conversations, we revised our manuscript to satisfy the objections that Dr. Brown presented in her letter, and it was our understanding that with the revisions it would be acceptable to Dr. Brown for us to include the biochemical data.We basically agree with Dr. Brown, as we stated in our report, concerning the lack of appropriate control values, but we point out that the results of diphenylhydantoin therapy were not judged solely on these biochemical determinations. The results were adjudged promising on the basis of clinically observed reduction of liver size, improvement in liver function studies, decrease in blood lactic

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