August 1975

Recurrence of Idiopathic Membranous Nephropathy in a Renal Allograft

Author Affiliations

From the departments of pathology, internal medicine, and surgery, Hennepin County Medical Center, Minneapolis.

Arch Intern Med. 1975;135(8):1101-1106. doi:10.1001/archinte.1975.00330080103016

Idiopathic membranous nephropathy, also termed "membranous glomerulonephritis," "extramembranous glomerulonephritis," "Ellis type 2 nephritis," and "epimembranous nephropathy,"1,2 is a well-recognized cause of nephrotic syndrome. Its clinical course and pathologic features are thoroughly verified. The presence of immunoglobulin-containing deposits in a subepithelial distribution along glomerular capillary loops and the formation of projections or spikes of basememt membrane between these deposits are commonly accepted pathologic criteria for the diagnosis.3,4 The disease is more common in adults than children and in men than women.2,4-6 Though the clinical course is variable, a certain percentage of patients progress to end-stage renal disease.3,6 Some of these patients will be treated by renal transplantation. The clinical course, however, of such patients after transplantation has yet to be thoroughly documented. This report describes the recurrence of idiopathic membranous nephropathy in a 47-year-old man several months after receiving a cadaver renal allograft.


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