November 1975

Evidence for Mild Reversible Hyperparathyroidism in Distal Renal Tubular Acidosis

Author Affiliations

From the Renal Division, Department of Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago, Pritzker School of Medicine, Chicago.

Arch Intern Med. 1975;135(11):1485-1489. doi:10.1001/archinte.1975.00330110075010

• Circulating levels of immunoreactive parathyroid hormone were measured in six patients with distal renal tubular acidosis before and during two years of longterm alkali therapy. Parathyroid hormone level was elevated modestly in five patients before treatment and fell, gradually, during treatment to normal or near normal levels. Urine calcium level fell, serum calcium level rose, and renal phosphorus reabsorption rose during treatment. Stopping treatment briefly caused reversion of serum parathyroid hormone and calcium levels and renal phosphorus reabsorption to pretreatment values within eight weeks. Mild hyperparathyroidism is present in renal tubular acidosis and reverses with alkali treatment.

(Arch Intern Med 135:1485-1489,1975)