January 1976

Mechanism of the Antidiuretic Effect of ß-Adrenergic Stimulation in Man

Author Affiliations

From the Department of Medicine, Cedars-Sinai Medical Center, West Los Angeles Veterans Administration Center, and the University of California School of Medicine, Los Angeles. Dr. Levi is now with the Hasharon Hospital, Petach-Tikva, Israel, and Dr. Kleeman is with the Hebrew University, Hadassah Medical School, Jerusalem.

Arch Intern Med. 1976;136(1):25-29. doi:10.1001/archinte.1976.03630010015003

β-Adrenergic stimulation with isoproterenol hydrochloride in animals causes an antidiuresis similar to antidiuretic hormone. This investigation was undertaken to determine whether isoproterenol inhibits water diuresis in man.

Seven young male volunteers were studied during water diuresis in three phases: (1 ) water-loading, (2) water-loading plus isoproterenol, and (3) water-loading plus isoproterenol plus propranolol hydrochloride.

Antidiuresis occurred 20 minutes following isoproterenol infusion (0.03μg to 0.06μg/kg/min) from a mean of 19.4 to 2.0 ml/min.

We found that antidiuresis is due to the hormonal (antidiuretic hormone) and nonhormonal changes (decreased glomerular filtration rate and renal plasma flow). These in turn are due to the cardiovascular effects of the drug.

(Arch Intern Med 136:25-29, 1976)