We evaluated the influence of severe disease in human kidneys (12 patients) on gentamicin sulfate accumulation characteristics in such tissue and compared the results with intrarenal tissue concentration data derived from the study of healthy dogs (54 kidneys) during variation in hydration and urinary pH.
Our results indicate that, in the management of pyelonephritis complicating preexisting renal disease, if the minimal inhibitory gentamicin concentration for an infecting organism is greater than the usual therapeutic and nontoxic serum levels of the compound, then it may be appropriate to use alternate antibiotics that demonstrate lesser reduction in tissue drug accumulation in diseased kidneys.
(Arch Intern Med 136:172-177, 1976)
Whelton A, Carter GG, Bryant HH, Fox L, Walker WG. Therapeutic Implications of Gentamicin Accumulation in Severely Diseased Kidneys. Arch Intern Med. 1976;136(2):172-176. doi:10.1001/archinte.1976.03630020028008