A 52-year-old man who had received levodopa because of idiopathic parkinsonism for four years was hospitalized with neuromyopathy, eosinophilia, and elevated levels of creatine phosphokinase, antinuclear antibody, and antibodies against γ-globulin. Examination of a muscle biopsy specimen showed multiple small vessel perivascular aggregates of mononuclear cells. Following discontinuation of levodopa, creatine phosphokinase values returned to normal, the anti-nuclear antibody disappeared, and the eosinophilia subsided. The patient was thought to have a hypersensitivity vasculitis, perhaps associated with levodopa therapy.
(Arch Intern Med 136:1055-1057, 1976)
Wolf S, Goldberg LS, Verity MA. Neuromyopathy and Periarteriolitis in a Patient Receiving Levodopa. Arch Intern Med. 1976;136(9):1055-1057. doi:10.1001/archinte.1976.03630090077019