Two boys are presented who fulfilled criteria for a diagnosis of idiopathic pulmonary hemosiderosis. A lung biopsy specimen from the first patient showed alveolar-capillary basement membrane abnormalities, together with abnormalities of capillary endothelial cells and hemosiderin-laden macrophages. A lung biopsy specimen from the second patient showed mainly capillary endothelial abnormalities and interstitial fibrosis. Both patients had a noticeable improvement in symptoms and relative stabilization of their roentgenographic and pulmonary function abnormalities following azathioprine therapy.
(Arch Intern Med 136:1145-1149, 1976)
Yeager H, Powell D, Weinberg RM, Bauer H, Bellanti JA, Katz S. Idiopathic Pulmonary HemosiderosisUltrastructural Studies and Response to Azathioprine. Arch Intern Med. 1976;136(10):1145–1149. doi:10.1001/archinte.1976.03630100057015