We describe a 52-year-old man who, following the discontinuation of massive intake of sodium bicarbonate, in the absence of renal insufficiency, developed progressive hyperkalemia and hyponatremia in association with hyporeninemic hypoaldosteronism. The mechanism of this syndrome is not known, but may involve suppression of the renin-angiotensin-aldosterone axis by chronic volume expansion.
(Arch Intern Med 136:1179-1180, 1976)
Oster JR, Perez GO, Rosen MS. Hyporeninemic Hypoaldosteronism After Chronic Sodium Bicarbonate Abuse. Arch Intern Med. 1976;136(10):1179-1180. doi:10.1001/archinte.1976.03630100087023