A patient developed benign nodular hyperplasia of the liver after long-term, high-dose estrogen therapy. A 10.5-cm benign liver nodule appeared after three years of high-dose estrogen therapy and was resected. Fourteen months later, while still receiving estrogen, a 4.5-cm nodule and multiple small nodules were seen on angiography. Four months after estrogen was discontinued, the large liver nodule disappeared and the smaller ones decreased.
(Arch Intern Med 113:357-359, 1977)
Aldinger K, Ben-Menachem Y, Whalen G. Focal Nodular Hyperplasia of the Liver Associated With High-Dosage Estrogens. Arch Intern Med. 1977;137(3):357–359. doi:10.1001/archinte.1977.03630150057016