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March 1977

Doxorubicin Hydrochloride-Associated Renal Failure

Author Affiliations

From the Departments of Medicine and Pathology, Jefferson Medical College, Philadelphia.

Arch Intern Med. 1977;137(3):385-388. doi:10.1001/archinte.1977.03630150079022

Doxorubicin hydrochloride (Adriamycin) therapy was associated with renal failure in a 78-year-old man. The pathophysiologic findings in this patient were similar to those seen following administration of structural analogues of doxorubicin. Daunorubicin hydrochloride, particularly, is known to cause renal failure in experimental animals. Renal function should be monitored in patients receiving doxorubicin.

(Arch Intern Med 137:385-388, 1977)