Frozen-thawed, deglycerolized RBCs can be substituted for saline-washed RBCs for transfusion of patients with paroxysmal nocturnal hemoglobinuria (PNH). The effect of transfusion is to decrease bone marrow production of RBCs, which results in a decreased percentage of complement-sensitive erythrocytes. In the presence of small numbers of complement-sensitive erythrocytes, major vascular surgery can be performed without hemolytic problems. This study suggests that the percentage of complement-sensitive RBCs, as well as the complement sensitivity of these cells, influence the severity of hemolysis in persons with PNH.
(Arch Intern Med 137:536-538, 1977)
Gockerman JP, Brouillard RP. RBC Transfusions in Paroxysmal Nocturnal Hemoglobinuria. Arch Intern Med. 1977;137(4):536-538. doi:10.1001/archinte.1977.03630160092019