Short-term studies with an artificial endocrine pancreas have provided insights into the pathophysiology of diabetes and demonstrated the ability of such a system to restore and maintain glucose homeostasis in human subjects given either their usual diet, a 50 gm oral glucose tolerance test, or a moderate level of physical exercise. Animals were used to demonstrate that a peripheral route of insulin delivery by the artificial pancreas is equivalent to the portal route.
(Arch Intern Med 137:639-649, 1977)
Albisser AM, Leibel BS, Zinman B, Murray FT, Zingg W, Botz CK, Denoga A, Marliss EB. Studies With an Artificial Endocrine Pancreas. Arch Intern Med. 1977;137(5):639-649. doi:10.1001/archinte.1977.03630170055015