June 1977

Ampicillin Sodium and Nephrotoxicity

Author Affiliations


Arch Intern Med. 1977;137(6):812. doi:10.1001/archinte.1977.03630180084025

To the Editor.—  In "Gentamicin-Associated Acute Renal Failure," which appeared in the October Archives (136:1101-1104, 1976), reference is made to the fact that ampicillin sodium has not been reported to be nephrotoxic. However, there are numerous reports in the literature that discuss tubulointerstitial nephritis due to ampicillin. These are summarized well in The Kidney.1 Additionally, although I do not agree with the authors' assertion that the acute renal failure they reported was associated with the use of gentamicin sulfate, it is interesting that their patients' recovery of renal function paralleled treatment and cure of the primary infection. Acute renal failure has been reported recently to be associated with suppurative infections, and recovery of renal function has been dependent on the cure of the underlying infection.2

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