July 1977

Aspergillus terreus Osteomyelitis

Author Affiliations

From the Department of Medicine, University of Chicago, Pritzker School of Medicine. Dr Seligsohn is now with the University of Illinois Hospital, Chicago.

Arch Intern Med. 1977;137(7):918-920. doi:10.1001/archinte.1977.03630190072018

Aspergillus terreus infection limited to the L1-2 disk space and first and second lumbar vertebrae developed in a patient not predisposed to invasive aspergillosis. The observation of morphologically distinct secondary spores (aleuriospores) on microscopic examination of open biopsy specimens permitted a preliminary identification of A terreus, which was confirmed by culture. The infection was eradicated with amphotericin B in a total dose of 3 gm. Aspergillus terreus is usually a saprophyte. The present case and four others collected from the literature establish this species as an invasive pathogen.

(Arch Intern Med. 137:918-920, 1977)