A patient who was receiving rifampin treatment for tuberculosis developed heterogenous light-chain proteinuria and insidious renal failure after a period of fluid restriction. The renal damage was characterized pathologically by an interstitial nephritis with invasive tubular casts and an associated renal vein thrombosis. The possible role of the light-chain proteinuria in the pathogenesis of the renal failure is discussed.
(Arch Intern Med 137:927-930, 1977)
Warrington RJ, Hogg GR, Paraskevas F, Tse KS. Insidious Rifampin-Associated Renal Failure With Light-Chain Proteinuria. Arch Intern Med. 1977;137(7):927–930. doi:10.1001/archinte.1977.03630190081021