August 1977

Erythrocytosis Associated With the Nephrotic Syndrome

Author Affiliations

From the Medical and Research Services, Veterans Administration Hospital, and the Departments of Medicine (Drs Sonneborn, Perez, Epstein, and Martelo) and Pathology (Dr Pardo), University of Miami School of Medicine. Dr Martelo is now with the University of Cincinnati College of Medicine.

Arch Intern Med. 1977;137(8):1068-1072. doi:10.1001/archinte.1977.03630200070019

A 23-year-old man had true erythrocytosis and the nephrotic syndrome. A renal biopsy specimen showed focal sclerosing glomerulonephritis and nephrosclerosis. Both serum and urinary erythropoietin levels were increased, and plasma renin activity was in the high normal range. The association of erythrocytosis and glomerulonephritis with the nephrotic syndrome is reviewed, and the uniqueness of this association is proposed. Finally, a dissociation between these hormones was demonstrated using water immersion to the neck as a suppressive maneuver.

(Arch Intern Med 137:1068-1072, 1977)