A 29-year-old woman suffered acute laryngospasm on taking the initial dose of propranolol hydrochloride for the treatment of hypertension associated with a hyperdynamic circulatory state. Hypersensitivity to the tartrazine additive used as a stabilizing agent in oral propranolol appeared the likely cause of anaphylaxis, although a direct hypersensitivity to propranolol itself could not be excluded.
(Arch Intern Med 137:1222-1223, 1977)
Morris SJ, Rossner SD, Hall WD. Allergic Laryngospasm on Initiating Oral Propranolol Therapy. Arch Intern Med. 1977;137(9):1222-1223. doi:10.1001/archinte.1977.03630210090027