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October 1977

Laboratory Diagnosis of Thrombosis

Arch Intern Med. 1977;137(10):1362-1364. doi:10.1001/archinte.1977.03630220010004

The laboratory detection of intravascular thrombin elaboration or fibrin deposition remains obscured by controversy related to methodology and to the interpretation of laboratory findings. Although a number of specific laboratory measurements have been developed, the test results are not specific for thrombosis due to the many functions of blood clotting. For example, physiological fibrin deposition for hemostasis occurs after surgery or during menstruation and pregnancy; fibrin deposition is a part of the pathological process accompanying a variety of disorders such as infections, tumors, collagen diseases, or cirrhosis. The laboratory tests must therefore always be interpreted within a given clinical context before concluding that intravascular thrombosis is responsible for the findings. In addition, the validity of the laboratory results is dependent on the care taken during blood collection, the selection of anticoagulant, and proper processing of the sample.

The measurement of fibrinogen/ fibrin degradation products (FDP/ fdp) have been applied to

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