November 1977

Tuberculous Meningitis in an Urban General Hospital

Author Affiliations

From the Division of Infectious Diseases, Department of Medicine, Henry Ford Hospital, Detroit (Drs Haas, Madhavan, Quinn, Cox, Fisher, and Burch), and the Department of Medicine, University of Michigan School of Medicine, Ann Arbor (Dr Quinn). Dr Haas is now with the Division of Infectious Diseases, Butterworth Hospital, Grand Rapids, Mich.

Arch Intern Med. 1977;137(11):1518-1521. doi:10.1001/archinte.1977.03630230014007

We analyzed the clinical and laboratory findings of 19 patients with tuberculous meningitis seen between 1966 and 1974 at the Henry Ford Hospital. Eighteen patients were adults at the time of diagnosis. In eight patients, the history suggested that the infection with the tubercle bacillus had occurred in the remote past. Cerebrospinal fluid analysis was often typical for tuberculous meningitis; stains for Mycobacterium tuberculosis were usually negative. Of 16 patients who were treated, five died and five suffered permanent neurological sequelae. The addition of rifampin to isoniazid therapy did not improve either survival or permanent sequelae. We were not able to analyze the effect of steroids on the disease.

(Arch Intern Med 137:1518-1521, 1977)