February 1978

Lower Esophageal Sphincter Pressure and Serum Gastrin Levels After Mapped Antrectomy

Author Affiliations

From the Gastroenterology Service, Department of Medicine, Faulkner Hospital and Tufts University School of Medicine (Dr Grace); Department of Surgery, Faulkner Hospital (Drs Grace and Osborne) and Massachusetts General Hospital (Dr Fischer); and Harvard Medical School (Drs Osborne and Fischer), Boston. Dr Eckardt is currently with Medizinische Universitatsklinik Mainz, Langenbeckstr, Germany.

Arch Intern Med. 1978;138(2):243-245. doi:10.1001/archinte.1978.03630260045015

We investigated the effect of mapped antrectomy with gastroduodenostomy on serum gastrin levels in fasting patients and resting lower esophageal sphincter (LES) pressure. Serum gastrin levels in fasting patients were lower in those who had an antrectomy without vagotomy (P <.05) as compared to control subjects or patients with antrectomy and vagotomy. Resting LES pressure was similar in patients and controls and was not affected by the presence or absence of vagotomy. These findings suggest that (1) mapped antrectomy and gastroduodenostomy without vagotomy are followed by a decrease in serum gastrin and (2) resting LES pressure is not affected by mapped antrectomy and a decrease in serum gastrin level.

(Arch Intern Med 138:243-245, 1978)