During an episode of pneumonia and multiple pulmonary thromboembolic events, an adult male patient with sickle cell-C hemoglobinopathy developed a severe anemia associated with rapidly increasing splenic size and diminished splenic uptake of technetium Tc 99m sulfur colloid, indicating diminished splenic function due to hypersequestration, a rare and noteworthy phenomenon in adult patients with sickle cell-C disease.
(Arch Intern Med 138:307-308, 1978)
Geola F, Kukreja SC, Schade SG. Splenic Sequestration With Sickle Cell-C Disease. Arch Intern Med. 1978;138(2):307-308. doi:10.1001/archinte.1978.03630260091024