March 1978

Contrast Media-Induced Oliguric Renal Failure

Author Affiliations

From the Division of Renal Diseases, Department of Medicine, Rhode Island Hospital, and the Division of Biological and Medical Sciences, Brown University, Providence, RI.

Arch Intern Med. 1978;138(3):381-384. doi:10.1001/archinte.1978.03630270031014

Seven patients had acute oliguric renal failure after intravenous urography (2), celiac arteriography (2), or cardiac angiography (3). Diatrizoate meglumine was the contrast media used in all of the cases. These patients had an average age of 63 years and six were 55 years of age or older. Diabetes mellitus, negative fluid balance before the procedure, underlying renal insufficiency, and hypertension were common, being present in three, four, five, and six of the patients respectively. Anuria or oliguria occurred within 24 hours of the procedure and persisted from 36 to 96 hours (72 hours average). The serum creatinine level rose significantly in all of the patients and reached a peak in two to seven days after the procedure. In six patients, recovery was complete by two to three weeks. The seventh patient experienced only partial recovery.

These cases taken together with a mounting number of recent reports suggest that contrast media-induced oliguric renal failure is more common than generally believed. Diabetes mellitus, older age, and underlying renal insufficiency seem to be important predisposing factors.

(Arch Intern Med 138:381-384, 1978)