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March 1978

Hyperchloremia and Negative Anion Gap Associated With Polymyxin B Administration

Author Affiliations

From the Division of Nephrology, Departments of Medicine, University of California, San Diego, School of Medicine and the Veterans Administration Hospital, San Diego.

Arch Intern Med. 1978;138(3):478-480. doi:10.1001/archinte.1978.03630270086029

A patient receiving polymyxin B sulfate intravenously for Gram-negative bacteremia developed progressive hyperchloremia and a negative "anion gap." Both abnormalities resolved following discontinuation of the drug. In vitro investigation suggested that the electrolyte abnormalities resulted from the polycationic properties of polymyxin B.

(Arch Intern Med 138:478-480, 1978)