[Skip to Content]
[Skip to Content Landing]
April 1978

Agranulocytosis Secondary to Pentazocine Therapy

Author Affiliations

From the Department of Internal Medicine, Sections of Hematology and Oncology (Dr Greenberg), and Endocrinology (Dr Walter), University of California, Davis/Sacramento Medical Center. Dr Hoppin is with the Woodland Clinic Medical Group, Woodland, Calif.

Arch Intern Med. 1978;138(4):533-534. doi:10.1001/archinte.1978.03630280015010

Agranulocytosis developed in three patients after prolonged oral pentazocine hydrochloride therapy. Two of the patients had a recurrence of their agranulocytosis within three weeks of reinstitution of pentazocine. Culture techniques in one patient indicate a probable metabolic effect.

(Arch Intern Med 138:533-534, 1978)