Agranulocytosis developed in three patients after prolonged oral pentazocine hydrochloride therapy. Two of the patients had a recurrence of their agranulocytosis within three weeks of reinstitution of pentazocine. Culture techniques in one patient indicate a probable metabolic effect.
(Arch Intern Med 138:533-534, 1978)
Hoppin EC, Greenberg BR, Walter RM. Agranulocytosis Secondary to Pentazocine Therapy. Arch Intern Med. 1978;138(4):533-534. doi:10.1001/archinte.1978.03630280015010