Five patients had fatal, disseminated candidiasis. At the onset of candidemia, a remarkably similar and distinctive triad of high fever, papular erythematous skin lesions, and diffuse severe muscle tenderness developed in each patient. This previously unreported clinical syndrome is sufficiently unique to justify a presumptive diagnosis of disseminated candidiasis and the use of empiric antifungal therapy pending culture and biopsy results.
(Arch Intern Med 138:544-546, 1978)
Jarowski CI, Fialk MA, Murray HW, Gottlieb GJ, Coleman M, Steinberg CR, Silver RT. Fever, Rash, and Muscle TendernessA Distinctive Clinical Presentation of Disseminated Candidiasis. Arch Intern Med. 1978;138(4):544-546. doi:10.1001/archinte.1978.03630280026013