April 1978

Fever, Rash, and Muscle TendernessA Distinctive Clinical Presentation of Disseminated Candidiasis

Author Affiliations

From the Divisions of Hematology-Oncology (Drs Jarowski, Fialk, Coleman, and Silver) and Infectious Diseases (Drs Murray and Steinberg), Department of Medicine, and the Department of Pathology (Dr Gottlieb), Cornell University Medical College, New York.

Arch Intern Med. 1978;138(4):544-546. doi:10.1001/archinte.1978.03630280026013

Five patients had fatal, disseminated candidiasis. At the onset of candidemia, a remarkably similar and distinctive triad of high fever, papular erythematous skin lesions, and diffuse severe muscle tenderness developed in each patient. This previously unreported clinical syndrome is sufficiently unique to justify a presumptive diagnosis of disseminated candidiasis and the use of empiric antifungal therapy pending culture and biopsy results.

(Arch Intern Med 138:544-546, 1978)