April 1978

HLA Antigens in Autoimmune Thyroid Diseases

Author Affiliations

From the Third Division, Department of Medicine, Kobe University School of Medicine, Ikuta-ku, Kobe, Japan (Drs Nakao, Kishihara, Baba, and Imura), the Kuma Thyroid Clinic, Kobe, Japan, (Dr Kuma), and the Transplantation Center, Hyogo Prefectual Nishinomiya Hospital, Nishinomiya, Japan (Dr Fukunishi).

Arch Intern Med. 1978;138(4):567-570. doi:10.1001/archinte.1978.03630280041016

HLA antigens were determined in 85 unrelated Japanese patients with Graves' disease and 56 patients with Hashimoto's thyroiditis, with the use of the microcytotoxicity test. HLA-Bw35 was found in 36.4% of 85 patients with Graves' disease compared with 13.3% of 150 normal control subjects. This difference in antigen frequency is significant at the level of P <.0005. The association with HLA-Bw35 in Japanese patients with Graves' disease is different from that with HLA-B8 in white patients.

In patients with Hashimoto's thyroiditis, HLA-Bw35 was also increased (28.5% of 56 patients) but not at a level of statistical significance (P <.05).

(Arch Intern Med 138:567-570, 1978)