April 1978

Myelofibrosis Associated With Multiple Myeloma

Author Affiliations

From the Division of Hematology, Department of Medicine, and Department of Oncology, Montefiore Hospital and Medical Center, Bronx, NY; and the Department of Pathology, New Rochelle (NY) Hospital.

Arch Intern Med. 1978;138(4):590-592. doi:10.1001/archinte.1978.03630280056019

Two patients had both multiple myeloma and myelofibrosis. One, who had both conditions, had autopsy confirmation of diagnosis three months later. The typical picture of agnogenic myeloid metaplasia with myelofibrosis developed in the second patient almost four years after the onset of κ light chain myeloma. At this time all evidence of multiple myeloma had disappeared, perhaps related to cyclophosphamide therapy. We were able to find two similar cases described in the English language literature. The two conditions may be related.

(Arch Intern Med 138:590-592, 1978)