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April 1978

Sjögren's Syndrome With Pseudolymphoma 13 Years After Hodgkin's Disease

Author Affiliations

From the Section of Medical Oncology (Dr Kennealey), the University Health Services (Dr Kaetz), and the Department of Pathology (Dr Smith), Yale University, New Haven, Conn.

Arch Intern Med. 1978;138(4):635-636. doi:10.1001/archinte.1978.03630280093029

A patient who had Hodgkin's disease at age 11 that was cured by radiation therapy, had nonspecific adenopathy at age 20. When he was 24 years old, the symptoms of Sjögren's syndrome developed, and this diagnosis was confirmed by biopsy of the lip. The patient subsequently had dyspnea and a diffuse pulmonary infiltrate which, at open lung biopsy, was diagnosed as pseudolymphoma and has responded to cytotoxic chemotherapy. This is the first reported case of Sjögren's syndrome and pseudolymphoma following the cure of a malignant lymphoma. The interrelationship between lymphoid malignancies, autoimmune diseases, and pseudolymphoma is herein discussed.

(Arch Intern Med 138:635-636, 1978)